Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502348 | 0.79 | PGK1 (0.37) | ALOX15ALOX12HPGDHSD17B10TSHR | |
| SCHEMBL12867289 | 0.74 | HPGD (0.32) | ESR1HPGDHSD17B10TSHRPGK1 | |
| SCHEMBL20666766 | 0.71 | LMNA (0.38) | ALOX15ALOX12GABRA1ESR1ESR2 | |
| SCHEMBL6466753 | 0.70 | NOS3 (0.40) | GABRA1GABRB2ESR1ESR2HPGD | |
| SCHEMBL13017041 | 0.68 | SIRT6 (0.36) | ESR1ESR2PDE10ANOS3NOS1 | |
| SCHEMBL12701773 | 0.68 | NOS3 (0.41) | GABRA1GABRB2ESR1ESR2PDE10A | |
| SCHEMBL18972448 | 0.68 | NOS3 (0.41) | ESR1ESR2PDE10ANOS3NOS1 | |
| SCHEMBL17996823 | 0.67 | ESR1 (0.68) | GABRA1GABRB2ESR1ESR2HPGD | |
| SCHEMBL17000231 | 0.67 | NOS3 (0.36) | ESR1NOS3NOS1NOS2 | |
| SCHEMBL17000224 | 0.67 | ESR1 (0.41) | ESR1ESR2HPGDPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136350-A1 | NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PFIZER INC. (US) | 2009-11-12 | — | — | WO | disclosed |