Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.47 |
| ▸ | RELA | Q04206 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975212 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2ARHTTLMNAKMT2A | |
| SCHEMBL7964002 | 0.76 | NPC1 (0.50) | SMN1; SMN2LMNAKMT2AMAPTRAB9A | |
| SCHEMBL7975345 | 0.73 | CA12 (0.34) | SMN1; SMN2LMNAMAPTHPGDALDH1A1 | |
| SCHEMBL7963933 | 0.73 | KDM4E (0.40) | SMN1; SMN2LMNAKMT2AMAPTNPC1 | |
| SCHEMBL7964121 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2ARHTTLMNAKMT2A | |
| SCHEMBL7964010 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2ARHTTLMNAKMT2A | |
| SCHEMBL7977607 | 0.71 | SMN1; SMN2 (0.66) | SMN1; SMN2ARHTTLMNAKMT2A | |
| SCHEMBL12604487 | 0.70 | NPC1 (0.73) | SMN1; SMN2HTTLMNAKMT2AMAPT | |
| Water SCHEMBL6484483 | 0.69 | SMN1; SMN2 (0.77) | SMN1; SMN2HTTLMNAKMT2AMAPT | |
| Water SCHEMBL6484487 | 0.69 | SMN1; SMN2 (0.77) | SMN1; SMN2HTTLMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |