Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Limonene SCHEMBL22013 | 1.00 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL1164294 | 1.00 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| D-Limonene SCHEMBL3988306 | 1.00 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL233098 | 1.00 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL1871533 | 1.00 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL8829 | 1.00 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| D-Limonene SCHEMBL787931 | 1.00 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL11163746 | 0.98 | LMNA (0.96) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL2852625 | 0.98 | LMNA (0.96) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL22769867 | 0.98 | LMNA (0.96) | LMNAALOX15ALDH1A1CYP1B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906351-B2 | 2,2′-furoin derivatives and use thereof to light skin | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| EP-2616040-B1 | 2,2'-FUROIN DERIVATIVES AND THEIR USE FOR SKIN LIGHTENING | MERCK PATENT GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-2616040-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHTEN SKIN | Merck Patent GmbH (DE) | 2013-07-24 | — | — | EP | disclosed |
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| WO-2012034629-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHTEN SKIN | MERCK PATENT GMBH (DE) | 2012-03-22 | — | — | WO | disclosed |
| EP-0284563-B1 | Milbemycin derivatives for combating parasites on livestock | CIBA GEIGY AG (CH) | 1994-06-15 | — | — | EP | disclosed |
| US-4973711-A | Composition for controlling parasites in productive livestock | CIBA-GEIGY CORPORATION (US) | 1990-11-27 | — | — | US | disclosed |
| US-4871719-A | MILBEMYCIN | CIBA-GEIGY CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0284563-A2 | Milbemycin derivatives for combating parasites on livestock | CIBA-GEIGY AG (CH) | 1988-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | TYR, ALDH1A2, MC1R | LMNA 1329/4885ALOX15 125/4885ALDH1A1 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.