Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of (-)-Limonene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 known ✓ | P36544 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (-)-Limonene SCHEMBL11163746 | 1.00 | LMNA (0.96) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| D-Limonene SCHEMBL3988306 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| D-Limonene SCHEMBL22013 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL233098 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL1871533 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL1164294 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| D-Limonene SCHEMBL787931 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL8829 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL797520 | 0.98 | LMNA (1.00) | LMNAALOX15ALDH1A1CYP1B1TSHR | |
| (-)-Limonene SCHEMBL22769867 | 0.96 | LMNA (0.96) | LMNAALOX15ALDH1A1CYP1B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858874-B1 | POLYMERISATION UNIT AND POLYMERISATION PROCESS | INEOS EUROPE AG (CH) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023232613-A1 | PROCESS FOR MANUFACTURING OF HIGHER FUNCTIONAL POLYISOBUTENES | BASF SE (DE) | 2023-12-07 | — | — | WO | disclosed |
| EP-3481547-B1 | POLYMERISATION PROCESS | INEOS EUROPE AG (CH) | 2023-06-07 | — | — | EP | disclosed |
| US-11478772-B2 | Polymerisation unit and polymerisation process | INEOS EUROPE AG (CH) | 2022-10-25 | — | — | US | disclosed |
| US-20210283573-A1 | POLYMERISATION UNIT AND POLYMERISATION PROCESS | INEOS EUROPE AG (CH) | 2021-09-16 | — | — | US | disclosed |
| EP-3858874-A1 | POLYMERISATION UNIT AND POLYMERISATION PROCESS | INEOS Europe AG (CH) | 2021-08-04 | — | — | EP | disclosed |
| US-11052373-B2 | Polymerisation unit and polymerisation process | INEOS EUROPE AG (CH) | 2021-07-06 | — | — | US | disclosed |
| US-11053331-B2 | Polymerisation process | INEOS EUROPE AG (CH) | 2021-07-06 | — | — | US | disclosed |
| US-20190309103-A1 | POLYMERISATION PROCESS | INEOS EUROPE AG (CH) | 2019-10-10 | — | — | US | disclosed |
| US-20190118158-A1 | POLYMERISATION UNIT AND POLYMERISATION PROCESS | INEOS EUROPE AG (CH) | 2019-04-25 | — | — | US | disclosed |
| US-20040171772-A1 | METHOD FOR PRODUCING HOMOPOLYMERS AND COPOLYMERS OF ISOBUTENE | BASF AKTIENGESELLSCHAFT (DE) | 2004-09-02 | — | — | US | disclosed |
| EP-1395620-A2 | METHOD FOR PRODUCING HOMOPOLYMERS AND COPOLYMERS OF ISOBUTENE | BASF AKTIENGESELLSCHAFT (DE) | 2004-03-10 | — | — | EP | disclosed |
| US-20040014911-A1 | Method for producing homopolymers and copolymers of isobutene | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-22 | — | — | US | disclosed |
| US-20040015029-A1 | Via cationic polymerization of isobutene in presence of initiator comprising Lewis acid, titanium chloride, borontrichloride, and 2-chloro-2-phenylpropane; for use as fuel/lubricant additives | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-22 | — | — | US | disclosed |
| EP-1347995-A2 | METHOD FOR PRODUCING HOMOPOLYMERS AND COPOLYMERS OF ISOBUTENE | BASF AKTIENGESELLSCHAFT (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1343829-A2 | METHOD FOR PRODUCING POLYISOBUTENES | BASF AKTIENGESELLSCHAFT (DE) | 2003-09-17 | — | — | EP | disclosed |
| WO-2003051932-A1 | POLYISOBUTENE AND POLYISOBUTENE DERIVATIVES FOR USE IN LUBRICANT COMPOSITIONS | BASF AKTIENGESELLSCHAFT (DE) | 2003-06-26 | — | — | WO | disclosed |
| WO-2002096964-A2 | METHOD FOR PRODUCING HOMOPOLYMERS AND COPOLYMERS OF ISOBUTENE | BASF AKTIENGESELLSCHAFT (DE) | 2002-12-05 | — | — | WO | disclosed |
| WO-2002048215-A2 | METHOD FOR PRODUCING POLYISOBUTENES | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-20 | — | — | WO | disclosed |
| WO-2002048216-A2 | METHOD FOR PRODUCING HOMOPOLYMERS AND COPOLYMERS OF ISOBUTENE | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040015029-A1 | Via cationic polymerization of isobutene in presence of initiator comprising Lewis acid, titanium chloride, borontrichloride, and 2-chloro-2-phenylpropane; for use as fuel/lubricant additives | FGB, CLTB, TAF11 | CHRNA7 2512/4885LMNA 3223/4885ALOX15 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.