Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 4/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669482 | 0.83 | USP2 (0.32) | — | |
| SCHEMBL14543317 | 0.74 | — | — | |
| SCHEMBL25094288 | 0.72 | HTR2A (0.33) | CHRNB2CHRNA4 | |
| SCHEMBL20690889 | 0.72 | ADORA2A (0.41) | — | |
| SCHEMBL7977462 | 0.71 | GAA (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL24597194 | 0.64 | AVPR1A (0.37) | — | |
| SCHEMBL24800360 | 0.61 | HTR2A (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL261803 | 0.61 | MAOA (0.40) | CDK4CDK6 | |
| SCHEMBL7273301 | 0.61 | CYP3A4 (0.32) | CACNA1BCHRNB2CHRNA4 | |
| SCHEMBL17953966 | 0.60 | HTR2A (0.40) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |