Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185922 | 0.76 | SLC6A2 (0.53) | CYP3A4CYP2D6SLC6A2SLC22A2SLC22A1 | |
| SCHEMBL7977462 | 0.69 | GAA (0.35) | CYP3A4CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9038711 | 0.65 | CES1 (0.44) | CYP2D6CYP1A2HTTMEN1KMT2A | |
| SCHEMBL7267151 | 0.63 | DAO (0.47) | MAPK1HTTSMN1; SMN2 | |
| SCHEMBL24669482 | 0.62 | USP2 (0.32) | CYP3A4CYP2D6HTT | |
| SCHEMBL24719048 | 0.61 | MEN1 (0.42) | CYP3A4CYP2D6SLC6A2SLC22A2SLC22A1 | |
| SCHEMBL8091908 | 0.61 | BRPF1 (0.41) | CYP2D6CYP1A2CHRM2CHRM1DRD2 | |
| SCHEMBL6283776 | 0.61 | KMT2A (0.43) | CYP3A4CYP2D6CYP1A2MEN1KMT2A | |
| SCHEMBL7975285 | 0.61 | PDE9A (0.32) | CACNA1BCHRNB2CHRNA4 | |
| SCHEMBL10541053 | 0.60 | POLB (0.46) | HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |