Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.31 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977458 | 0.84 | HDAC1 (0.37) | GAAHDAC1CYP11B1CYP11B2ADORA3 | |
| SCHEMBL24800360 | 0.81 | HTR2A (0.35) | GAACYP11B1CYP11B2LATS1CYP3A4 | |
| SCHEMBL24669482 | 0.76 | USP2 (0.32) | GSK3BCYP3A4 | |
| SCHEMBL4013751 | 0.72 | BRPF1 (0.50) | GAAHDAC1ADORA3ALDH1A1MAPT | |
| SCHEMBL12396551 | 0.71 | GAA (0.40) | GAACYP11B1CYP11B2ADORA3ADORA2A | |
| SCHEMBL7975285 | 0.71 | PDE9A (0.32) | CHRNB2CHRNA4 | |
| SCHEMBL20011113 | 0.71 | CDC7 (0.39) | CYP11B1CYP11B2ADORA3ADORA2AGSK3A | |
| SCHEMBL20571451 | 0.71 | BRPF1 (0.62) | CYP11B1CYP11B2ADORA3ADORA2AGSK3A | |
| SCHEMBL7273301 | 0.69 | CYP3A4 (0.32) | HDAC1CYP3A4CHRNA7CHRNB2CHRNB4 | |
| SCHEMBL261618 | 0.68 | CYP3A4 (0.40) | GAACYP11B1CYP11B2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |