Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975339 | 0.90 | AR (0.49) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7980407 | 0.90 | NPC1 (0.48) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7963991 | 0.88 | LMNA (0.45) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7980374 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7980183 | 0.84 | AR (0.46) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7974453 | 0.83 | NPC1 (0.50) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7974403 | 0.83 | RAB9A (0.47) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7964005 | 0.82 | POLB (0.46) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7974397 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL7977473 | 0.81 | RAB9A (0.48) | SMN1; SMN2LMNARAB9ANPC1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |