Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240548 | 0.92 | AKT1 (0.64) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL2239637 | 0.86 | AKT1 (0.67) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL21753106 | 0.76 | ALDH1A1 (0.76) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL328335 | 0.75 | AKT1 (1.00) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL7824834 | 0.73 | ALDH1A1 (0.78) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL4556022 | 0.72 | P2RY1 (0.83) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| Sulfadimethoxine SCHEMBL29363944 | 0.72 | LMNA (1.00) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| Sulfadimethoxine SCHEMBL93845 | 0.72 | LMNA (1.00) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL328334 | 0.71 | ALOX12 (0.81) | AKT1SMN1; SMN2KMT2AALDH1A1HTT | |
| Sulfadimethoxine SCHEMBL2430279 | 0.71 | LMNA (0.97) | AKT1SMN1; SMN2KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005534-A2 | PROTEASOME INHIBITORS FOR SELECTIVELY INDUCING APOPTOSIS IN CANCER CELLS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2010-01-14 | — | — | WO | disclosed |