SCHEMBL7975943

SCHEMBL7975943

CCc1cc(OCC=C(Cl)Cl)cc(CC)c1OCCCNc1ccc(Cl)cc1F

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HTT P42858 1/20 0.34
TRPM5 Q9NZQ8 1/20 0.34
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 5/20 0.32
TDP1 Q9NUW8 2/20 0.32
ALPG P10696 1/20 0.32
LMNA P02545 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
POLB P06746 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
EGFR P00533 1/20 0.32
KDR P35968 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MAP2K1 Q02750 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7965903 0.88 TRPM5 (0.34) NPSR1SMN1; SMN2HTTTRPM5ALDH1A1
SCHEMBL7982370 0.87 MAPT (0.37) SMN1; SMN2HTTALDH1A1KDM4EMAPT
SCHEMBL7975945 0.83 POLB (0.38) SMN1; SMN2ALDH1A1MAPTTDP1LMNA
SCHEMBL7979221 0.83 HTT (0.42) NPSR1HTTALDH1A1KDM4EMAPT
SCHEMBL7965828 0.82 HTT (0.40) NPSR1HTTALDH1A1KDM4EMEN1
SCHEMBL7976320 0.81 HTT (0.40) SMN1; SMN2HTTALDH1A1MAPTLMNA
SCHEMBL7977810 0.80 NPSR1 (0.34) NPSR1SMN1; SMN2HTTTRPM5ALDH1A1
SCHEMBL7979432 0.80 MAPT (0.37) SMN1; SMN2HTTALDH1A1MAPTLMNA
SCHEMBL7977787 0.79 HTT (0.40) NPSR1HTTALDH1A1KDM4EMAPT
SCHEMBL8408710 0.78 HTT (0.44) NPSR1HTTALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214835-B1 CONTROLLING INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US disclosed