Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28975433 | 0.80 | PTGDR2 (0.72) | PTGDR2FFAR1CYP2C9 | |
| SCHEMBL14589545 | 0.77 | MAPT (0.51) | FFAR1CYP2C9 | |
| SCHEMBL8637573 | 0.77 | KMT2A (0.60) | PTGDR2 | |
| SCHEMBL7990328 | 0.74 | KMT2A (0.50) | PTGDR2 | |
| SCHEMBL28975431 | 0.74 | FFAR1 (0.64) | PTGDR2FFAR1CYP2C9 | |
| SCHEMBL1368495 | 0.73 | PTGDR2 (1.00) | PTGDR2CYP2C9 | |
| SCHEMBL7987656 | 0.73 | LTB4R (0.66) | — | |
| SCHEMBL7994027 | 0.73 | LTB4R (0.66) | — | |
| SCHEMBL5907838 | 0.73 | KMT2A (0.73) | CYP2C9 | |
| SCHEMBL7976206 | 0.72 | LTB4R (0.67) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |