Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.67 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 4/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988234 | 0.81 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7988237 | 0.81 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7988242 | 0.81 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7994027 | 0.80 | LTB4R (0.66) | LTB4RLTB4R2MAOBPOLBSMN1; SMN2 | |
| SCHEMBL7987656 | 0.80 | LTB4R (0.66) | LTB4RLTB4R2MAOBPOLBSMN1; SMN2 | |
| SCHEMBL5007118 | 0.79 | HTR1A (0.64) | LTB4RLTB4R2L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL8637573 | 0.78 | KMT2A (0.60) | LTB4RLTB4R2L3MBTL1TSHRPOLB | |
| SCHEMBL8408039 | 0.77 | PKM (0.60) | MAOBPOLBKMT2AHSD17B10LMNA | |
| SCHEMBL13098020 | 0.77 | LMNA (0.53) | L3MBTL1KMT2ALMNA | |
| SCHEMBL7990328 | 0.75 | KMT2A (0.50) | L3MBTL1POLBSMN1; SMN2GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |