Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 3/20 | 0.41 |
| ▸ | TYMS | P04818 | 3/20 | 0.41 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450587 | 0.85 | TNF (0.46) | LMNATHRBDHFRSLC19A1MAPT | |
| SCHEMBL6446130 | 0.85 | TNF (0.46) | LMNATHRBDHFRSLC19A1MAPT | |
| SCHEMBL6651478 | 0.80 | DHFR (0.54) | LMNADHFRTYMSSLC19A1MAPT | |
| SCHEMBL7990232 | 0.75 | TYMS (0.78) | DHFRTYMSSLC19A1 | |
| SCHEMBL7501783 | 0.75 | TYMS (0.78) | DHFRTYMSSLC19A1 | |
| SCHEMBL24696967 | 0.75 | DHFR (0.41) | LMNATHRBDHFRTYMSSLC19A1 | |
| SCHEMBL31134672 | 0.74 | NPC1 (0.55) | LMNATHRBDHFRSLC19A1MAPT | |
| SCHEMBL25032020 | 0.73 | ALOX15 (0.40) | LMNATHRBMAPTKDM4EALOX15 | |
| SCHEMBL24696964 | 0.72 | DHFR (0.41) | LMNATHRBDHFRTYMSSLC19A1 | |
| SCHEMBL22006754 | 0.69 | DHFR (0.43) | LMNATHRBDHFRTYMSSLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306865-B1 | SYNTHASE INHIBITORS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-10-23 | — | — | US | disclosed |
| WO-2001009125-A1 | NOVEL 8-CARBONYL CHROMAN DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |