Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.52 |
| ▸ | ITGAV | P06756 | 15/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.52 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451864 | 1.00 | ITGB3 (0.52) | ITGB3ITGAVITGA2BEGLN2EGLN1 | |
| SCHEMBL7448493 | 0.91 | ITGB3 (0.43) | ITGB3ITGAVITGA2BCTSKL3MBTL1 | |
| SCHEMBL7974296 | 0.91 | ITGB3 (0.43) | ITGB3ITGAVITGA2BCTSKL3MBTL1 | |
| SCHEMBL5626363 | 0.74 | ITGB3 (0.63) | ITGB3ITGAVITGA2BEGLN2EGLN1 | |
| SCHEMBL5626356 | 0.74 | ITGB3 (0.63) | ITGB3ITGAVITGA2BEGLN2EGLN1 | |
| SCHEMBL7452995 | 0.73 | ITGB3 (0.57) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL7453000 | 0.73 | ITGB3 (0.57) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL31370468 | 0.69 | CTSK (0.61) | ITGB3ITGA2BPPARGPPARACTSK | |
| SCHEMBL7511424 | 0.69 | CTSK (0.61) | ITGB3ITGA2BPPARGPPARACTSK | |
| SCHEMBL7240669 | 0.69 | ITGB3 (0.74) | ITGB3ITGAVITGA2BPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274620-B1 | 2-BENZENESULFONYLAMINO-3-((5-BROMO-THIOPHENE-2-CARBONYL)-AMINO )PROPIONIC ACID-TERT-BUTYL ESTERS AS ANGIOGENESIS INHIBITORS; ANTICARCINOGENIC AGENTS; OSTEOPOROSIS, RESTENOSIS, AND OCULAR NEOVASCULARIZATION | BIOCHEM PHARMA INC. (CA) | 2001-08-14 | — | — | US | disclosed |