Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Nitrobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CRHBP | P24387 | 3/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrobenzene SCHEMBL21381350 | 0.98 | ALDH1A1 (0.70) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Nitrobenzene SCHEMBL27935673 | 0.91 | ALDH1A1 (0.67) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Nitrobenzene SCHEMBL4658242 | 0.91 | ALDH1A1 (0.80) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Nitrobenzene SCHEMBL28164256 | 0.88 | ALDH1A1 (0.76) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Alcohol SCHEMBL28329576 | 0.88 | TSHR (0.61) | ALDH1A1LMNACES1TSHRMAPT | |
| Nitrobenzene SCHEMBL1954442 | 0.88 | ALDH1A1 (0.84) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Alcohol SCHEMBL28158022 | 0.88 | POLB (0.66) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Nitrobenzene SCHEMBL5406282 | 0.87 | ALDH1A1 (0.67) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Nitrobenzene SCHEMBL11740952 | 0.86 | ALDH1A1 (0.73) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 | |
| Nitrobenzene SCHEMBL28079896 | 0.86 | ALDH1A1 (0.73) | ALDH1A1LMNACRHBPCRHR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109126823-B | Method for preparing aniline by selective hydrogenation of nitrobenzene under catalysis of catalyst | 江西理工大学 | 2021-08-17 | — | — | CN | claimed |
| CN-108238948-B | Method for preparing alpha-o-nitrobenzene ethanol by oxidizing o-nitroethylbenzene without catalyst oxygen | 浙江工业大学 | 2020-12-25 | — | — | CN | claimed |
| US-10777361-B2 | Hybrid capacitor and method of manufacturing a capacitor | KEMET ELECTRONICS CORPORATION (US) | 2020-09-15 | — | — | US | claimed |
| CN-117920120-A | Catalytic reactor and application thereof | 常州锐蓁材料科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4261217-A9 | COMPOUND FOR RNA CAPPING AND APPLICATION OF COMPOUND | Guangzhou Henovcom Bioscience Co., Ltd. (CN) | 2023-12-27 | — | — | EP | disclosed |
| US-20230340009-A1 | COMPOUNDS FOR RNA CAPPING AND USES THEREOF | GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| EP-4261217-A1 | COMPOUND FOR RNA CAPPING AND APPLICATION OF COMPOUND | Guangzhou Henovcom Bioscience Co., Ltd. (CN) | 2023-10-18 | — | — | EP | disclosed |
| CN-115531610-A | Fiber composite membrane, preparation method and application thereof | 贵州医科大学附属医院 | 2022-12-30 | — | — | CN | disclosed |
| CN-111085241-B | Method for preparing aniline by nitrobenzene hydrogenation and preparation method of catalyst thereof | 湘潭大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-112960858-B | Sewage treatment process based on hollow fiber membrane | 杭州楠大环保科技有限公司 | 2022-05-24 | — | — | CN | disclosed |
| US-11177076-B2 | Conductive polymer capacitor for improved reliability | KEMET ELECTRONICS CORPORATION (US) | 2021-11-16 | — | — | US | disclosed |
| CN-1396833-A | Integrin expression inhibitors | EISAI CO LTD (JP) | 2003-02-12 | — | — | CN | disclosed |
| CN-1325540-A | Polishing liquid for metal and polishing method | HITACHI CHEMICAL CO LTD (JP) | 2001-12-05 | — | — | CN | disclosed |
| US-6294696-B1 | PREPARING CATALYST COMPRISING SUPPORT, METAL FROM PERIODIC GROUP VIII AND SELECTED ADDITIONAL ELEMENT BY INTRODUCING AQUEOUS SOLUTION OF ORGANOMETALLIC COMPOUND INTO SUPPORT, DRYING, CALCINING, REDUCING; USING AS HYDROGENATION CATALYST | INSTITUT FRANCAIS DU PETROLE (FR) | 2001-09-25 | — | — | US | disclosed |
| CN-1241181-A | Pharmaceutical compounds | XENOVA LTD (GB) | 2000-01-12 | — | — | CN | disclosed |
| CN-1184423-A | Nodulisporic acid derivatives | MERCK & CO INC (US) | 1998-06-10 | — | — | CN | disclosed |
| EP-0552558-B1 | 1,5-Diphenyl-1H-1,2,4-triazole-3-carboxamide derivatives, process for preparation of the same, antifungal composition comprising the same | KUREHA CHEMICAL IND CO LTD (JP) | 1996-05-22 | — | — | EP | disclosed |
| EP-0562479-A1 | 1-Phenyl-5-heterocyclic-1H-1, 2,4-triazole-3-carboxamide derivates, process for preparation of the same, and fungicidal composition comprising the same | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-09-29 | — | — | EP | disclosed |
| EP-0552558-A1 | 1,5-Diphenyl-1H-1,2,4-triazole-3-carboxamide derivatives, process for preparation of the same, antifungal composition comprising the same | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-07-28 | — | — | EP | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230340009-A1 | COMPOUNDS FOR RNA CAPPING AND USES THEREOF | RNGTT, RNMT, NSUN2 | ALDH1A1 2179/4885LMNA 2824/4885CRHBP 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.