Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL783038 | 0.89 | LMNA (0.42) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL755478 | 0.80 | LMNA (0.46) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL754385 | 0.78 | L3MBTL1 (0.45) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL781929 | 0.73 | LMNA (0.43) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL765579 | 0.71 | LMNA (0.51) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL757397 | 0.70 | RAB9A (0.46) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL783030 | 0.69 | LMNA (0.65) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL7425441 | 0.68 | L3MBTL1 (0.60) | LMNARAB9AHTTNPC1TP53 | |
| SCHEMBL3839703 | 0.68 | EPHX1 (0.63) | RAB9ANPC1GAASMN1; SMN2TSHR | |
| SCHEMBL5165370 | 0.66 | L3MBTL1 (0.54) | LMNARAB9AHTTNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035216-A1 | DIHYDROBENZOXATHIAZEPINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE AS AMPA RECEPTOR MODULATORS | LES LABORATOIRES SERVIER (FR) | 2012-03-22 | — | — | WO | disclosed |