Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964060 | 0.79 | SMN1; SMN2 (0.62) | ARCYP2D6SMN1; SMN2MAPTMEN1 | |
| SCHEMBL7963845 | 0.70 | PTGS2 (0.50) | CYP2D6SMN1; SMN2KDM4EMAPTHTR1A | |
| SCHEMBL7977647 | 0.70 | PTGS2 (0.50) | SMN1; SMN2KDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL7963575 | 0.67 | PDCD1 (0.43) | CYP2D6SMN1; SMN2KDM4EMAPTCACNA1G | |
| SCHEMBL7963860 | 0.67 | ALDH1A1 (0.42) | TLR8KDM4EMAPTCACNA1GCACNA1H | |
| SCHEMBL10532274 | 0.65 | AR (0.55) | ARALOX5KDM4EMAPTMEN1 | |
| SCHEMBL10503421 | 0.64 | BRS3 (0.56) | ARALOX5SMN1; SMN2KDM4EMAPT | |
| SCHEMBL7994171 | 0.64 | PDE5A (0.58) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19121724 | 0.63 | HTR1B (0.53) | CYP2D6KDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL28668279 | 0.63 | AR (0.60) | ARALOX5PDE5AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |