Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401323 | 0.88 | PTGS1 (0.35) | PTGS1PTGS2HSD17B10ALOX15ALDH1A1 | |
| SCHEMBL6904683 | 0.79 | PTGS1 (0.41) | PTGS1PTGS2HSD17B10ALOX15CA12 | |
| SCHEMBL8445530 | 0.73 | ALDH1A1 (0.46) | PTGS1PTGS2HSD17B10ALDH1A1HPGD | |
| SCHEMBL7401321 | 0.69 | PTGS1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL6911268 | 0.68 | CA2 (0.39) | PTGS1PTGS2HSD17B10CA12CA2 | |
| SCHEMBL6908277 | 0.67 | PTGS1 (0.41) | PTGS1PTGS2CA12CA2CA9 | |
| SCHEMBL1131536 | 0.64 | CA2 (0.42) | PTGS1PTGS2HSD17B10CA12CA2 | |
| SCHEMBL3808200 | 0.63 | CA1 (0.45) | PTGS1PTGS2CA12CA2CA9 | |
| SCHEMBL464729 | 0.63 | PTGS1 (0.43) | PTGS1PTGS2CA12CA2CA9 | |
| SCHEMBL6646111 | 0.62 | GSK3B (0.44) | PTGS1PTGS2ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331637-B1 | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION | 2001-12-18 | — | — | US | disclosed |