Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 8/20 | 0.34 |
| ▸ | PRKACA | P17612 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.31 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386406 | 0.77 | HSD17B10 (0.45) | CDC7PRKACACDK8ACVR1MAP4K2 | |
| SCHEMBL7978699 | 0.76 | MAPT (0.52) | CDC7MAPK1HSD17B10MAPT | |
| SCHEMBL7447432 | 0.76 | HSD17B10 (0.47) | CDC7PRKACACDK8ACVR1MAP4K2 | |
| SCHEMBL5381026 | 0.74 | AR (0.44) | CDC7CDK2GSK3BHSD17B10MAPT | |
| SCHEMBL7978276 | 0.72 | HRH4 (0.49) | — | |
| SCHEMBL7989788 | 0.72 | ALDH1A1 (0.58) | MAPK1PARP1HSD17B10MAPT | |
| SCHEMBL7990353 | 0.71 | KDM4E (0.52) | MAPK1HSD17B10 | |
| SCHEMBL7996467 | 0.71 | CDC7 (0.38) | CDC7PRKACACDK8ACVR1MAP4K2 | |
| SCHEMBL7978522 | 0.71 | — | — | |
| SCHEMBL7989669 | 0.69 | KCNH2 (0.35) | CDC7PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001070728-A1 | 2-[NITROGEN-HETEROCYCLIC]PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | claimed |