Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978954 | 0.81 | ALDH1A1 (0.43) | ALDH1A1OPRM1SIGMAR1TSHRMEN1 | |
| SCHEMBL7985647 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HDAC6TSHRMEN1KMT2A | |
| SCHEMBL7978926 | 0.78 | ALDH1A1 (0.43) | ALDH1A1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL2583273 | 0.77 | POLQ (0.47) | POLQALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5242161 | 0.77 | P2RY1 (0.39) | ALDH1A1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL7978886 | 0.75 | KMT2A (0.48) | ALDH1A1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL8691853 | 0.74 | KMT2A (0.41) | ALDH1A1DHODHTSHRMEN1KMT2A | |
| SCHEMBL27335438 | 0.74 | TRPV1 (0.48) | POLQTRPV1HSD11B1HDAC6TSHR | |
| SCHEMBL7968895 | 0.73 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15206612 | 0.73 | TDP1 (0.51) | ALDH1A1TSHRMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| CN-1252068-A | 3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions containing the same | JAPAN TOBACCO INC (JP) | 2000-05-03 | — | — | CN | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |