Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.43 |
| ▸ | PRKACA | P17612 | 5/20 | 0.43 |
| ▸ | PRKX | P51817 | 4/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990139 | 0.83 | MAPT (0.58) | MAPTKDM4EMAPK1LMNANPC1 | |
| SCHEMBL25256451 | 0.78 | MAPT (0.46) | MAPTKDM4ENPC1RAB9AABCG2 | |
| SCHEMBL4061462 | 0.77 | DHPS (0.49) | MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL7582159 | 0.76 | HPGD (0.47) | MAPTKDM4ELMNANPC1RAB9A | |
| SCHEMBL7700541 | 0.74 | MAPT (0.48) | MAPTKDM4EMAPK1LMNANPC1 | |
| SCHEMBL8382254 | 0.70 | NPC1 (0.62) | NPC1RAB9AABCB1CLK4CYP3A4 | |
| SCHEMBL18343119 | 0.69 | CYP1A2 (0.55) | MAPTKDM4EMAPK1LMNANPC1 | |
| SCHEMBL4059458 | 0.69 | L3MBTL1 (0.52) | MAPTMAPK1CYP3A4CYP2C9 | |
| SCHEMBL7297004 | 0.69 | KDM4E (0.48) | MAPTKDM4EMAPK1LMNANPC1 | |
| SCHEMBL13167638 | 0.67 | SMN1; SMN2 (0.72) | MAPTKDM4EALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |