Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | DHPS | P49366 | 3/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979230 | 0.83 | MAPT (0.58) | MAPTKDM4ELMNAMAPK1NPC1 | |
| SCHEMBL7303236 | 0.83 | CLK4 (0.51) | MAPTKDM4ELMNAMAPK1RAB9A | |
| SCHEMBL7298473 | 0.79 | DHPS (0.47) | MAPTKDM4ELMNAMAPK1NPC1 | |
| SCHEMBL25270126 | 0.78 | MAPT (0.46) | MAPTKDM4ENPC1RAB9ADHPS | |
| SCHEMBL9423667 | 0.78 | NPC1 (0.52) | MAPTKDM4ELMNAMAPK1NPC1 | |
| SCHEMBL7990440 | 0.77 | EDNRB (0.55) | — | |
| SCHEMBL4071996 | 0.77 | DHPS (0.67) | NPC1RAB9ADHPSTP53SMN1; SMN2 | |
| SCHEMBL7991567 | 0.76 | EDNRA (0.62) | — | |
| SCHEMBL7589698 | 0.76 | ALDH1A1 (0.47) | MAPTKDM4ENPC1RAB9ADHPS | |
| SCHEMBL15591631 | 0.75 | NPC1 (0.54) | MAPTKDM4ELMNAMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |