SCHEMBL7979434

SCHEMBL7979434

CCc1cc(OCC=C(Cl)Cl)cc(CC)c1OCCCNC(=O)c1ccc(C(F)(F)F)cc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RHOC P08134 1/20 0.39
RHOA P61586 1/20 0.39
ESRRG P62508 1/20 0.38
CES2 O00748 1/20 0.38
SLC6A9 P48067 2/20 0.36
FLT1 P17948 1/20 0.36
FLT4 P35916 1/20 0.36
KDR P35968 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.35
PPARD Q03181 8/20 0.35
PPARA Q07869 6/20 0.35
PPARG P37231 4/20 0.35
TRPV1 Q8NER1 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
BACE1 P56817 1/20 0.34
BACE2 Q9Y5Z0 1/20 0.34
SCN9A Q15858 1/20 0.34
GPR52 Q9Y2T5 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7982372 0.91 PPARD (0.44) RHOCRHOAPPARDPPARAPPARG
SCHEMBL7965747 0.89 RHOC (0.42) RHOCRHOAESRRGCES2FLT1
SCHEMBL7976273 0.88 RHOC (0.47) RHOCRHOAMRGPRX4PPARDPPARA
SCHEMBL7975921 0.85 RHOC (0.44) RHOCRHOAMRGPRX4PPARDPPARA
SCHEMBL7977745 0.85 SCN9A (0.47) RHOCRHOAPPARDPPARGSCN9A
SCHEMBL7979432 0.84 MAPT (0.37) PPARDPPARAPPARGNPC1RAB9A
SCHEMBL7979083 0.83 RHOC (0.44) RHOCRHOAMRGPRX4PPARDTRPV1
SCHEMBL7979400 0.82 FLT1 (0.37) RHOCRHOAESRRGCES2FLT1
SCHEMBL7979538 0.82 SCN9A (0.44) RHOCRHOAPPARDPPARGSCN9A
SCHEMBL7976269 0.81 HTT (0.40) RHOCRHOAPPARDPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214835-B1 CONTROLLING INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US disclosed
EP-0824514-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-09-06 EP disclosed
US-6028100-A Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-02-22 US disclosed
US-5952386-A EXCELLENT INSECTICIDAL ACTIVITY FOR THE CONTROL OF NOXIOUS INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-14 US disclosed
EP-0824514-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1998-02-25 EP disclosed
WO-1996033160-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-10-24 WO disclosed