Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | MMP2 | P08253 | 3/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | MMP1 | P03956 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP13 | P45452 | 2/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16013940 | 0.81 | MMP2 (0.48) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL27461771 | 0.79 | CA1 (0.56) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL12054697 | 0.79 | CA1 (0.53) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL2333640 | 0.79 | ALDH1A1 (0.59) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL302571 | 0.78 | GAA (0.55) | CA2MMP2CA1MMP1MMP9 | |
| Hydrochloric Acid SCHEMBL2640192 | 0.77 | GAA (0.54) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL1068742 | 0.76 | MMP1 (0.50) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL8779438 | 0.76 | CA2 (0.61) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL10005288 | 0.75 | MMP2 (0.67) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL3013616 | 0.75 | CA1 (0.51) | CA2MMP2CA1MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616445-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | Aragon Pharmaceuticals, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037411-A9 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012037411-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |