Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.65 |
| ▸ | CRHBP | P24387 | 2/20 | 0.63 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.63 |
| ▸ | FAAH | O00519 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307965 | 0.84 | KDM4E (1.00) | KDM4ELMNAMAPTALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL16825180 | 0.81 | ACHE (0.64) | KDM4ELMNAMAPTALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL9750244 | 0.80 | TDP1 (0.52) | KDM4ELMNAMAPTALDH1A1GAA | |
| SCHEMBL31010166 | 0.80 | ACHE (0.66) | KDM4ELMNAMAPTALDH1A1GAA | |
| SCHEMBL807336 | 0.80 | ACHE (0.66) | KDM4ELMNAMAPTALDH1A1GAA | |
| SCHEMBL3921135 | 0.78 | ACHE (0.68) | KDM4ELMNAMAPTALDH1A1GAA | |
| SCHEMBL13700903 | 0.77 | CRHBP (1.00) | KDM4ELMNAMAPTALDH1A1GAA | |
| SCHEMBL30294879 | 0.77 | CRHBP (1.00) | KDM4ELMNAMAPTALDH1A1GAA | |
| SCHEMBL9975980 | 0.77 | FAAH (0.59) | KDM4ELMNAMAPTALDH1A1GAA | |
| SCHEMBL1787096 | 0.76 | KDM4E (0.68) | KDM4ELMNAMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996005799-A1 | HAIR DYE | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1996-02-29 | — | — | WO | claimed |
| US-8546397-B2 | DNA methylation inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | disclosed |
| US-8546397-B2 | DNA methylation inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | disclosed |
| WO-2012087889-A2 | DNA METHYLATION INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20120157465-A1 | DNA METHYLATION INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157465-A1 | DNA METHYLATION INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2010003475-A2 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |
| EP-0825172-B1 | Synthesis of 1-acetoxy-2-methylnaphthalene | BRISTOL MYERS SQUIBB CO (US) | 2000-04-26 | — | — | EP | disclosed |
| EP-0825172-A1 | Synthesis of 1-acetoxy-2-methylnaphthalene | Bristol-Myers Squibb Company (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5670698-A | Synthesis of 1-acetoxy-2-methylnaphthalene | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-09-23 | — | — | US | disclosed |
| WO-1996005799-A1 | HAIR DYE | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1996-02-29 | — | — | WO | disclosed |
| US-5420362-A | Synthesis of 2-methyl-1-naphthol | CLAIROL, INC. (US) | 1995-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157465-A1 | DNA METHYLATION INHIBITORS | MECP2, DNMT1, DNMT3B | KDM4E 427/4885LMNA 614/4885MAPT 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.