Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135234 | 0.85 | L3MBTL1 (0.58) | ALDH1A1KDM4EMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL9097378 | 0.82 | MELK (0.41) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL18430437 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL7021001 | 0.80 | MAPT (0.52) | ALDH1A1KDM4EMAPTHPGDGAA | |
| SCHEMBL27469752 | 0.79 | KMT2A (0.40) | ALDH1A1KDM4EMAPTRXFP1HPGD | |
| SCHEMBL3401657 | 0.79 | GRIA4 (0.45) | ALDH1A1KDM4EMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL5642877 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTHPGDGAA | |
| SCHEMBL3404543 | 0.78 | GRIA2 (0.42) | ALDH1A1KDM4EMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL7982273 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL4471909 | 0.76 | MELK (0.60) | ALDH1A1KDM4EMAPTSMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225310-B1 | Fused 1,2,4-thiadiazine derivatives, their preparation and use | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1000066-A1 | FUSED 1,2,4-THIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999003861-A1 | FUSED 1,2,4-THIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-01-28 | — | — | WO | disclosed |
| EP-0609371-B1 | THIENOPYRAZINE-2,3-DIONES USEFUL FOR TREATING CNS DISORDERS, AND THEIR PREPARATION. | NOVO NORDISK AS (DK) | 1996-04-24 | — | — | EP | disclosed |
| EP-0483683-B1 | Thienoimidazole derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-02-28 | — | — | EP | disclosed |
| US-5463073-A | Angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-31 | — | — | US | disclosed |
| EP-0609371-A1 | THIENOPYRAZINE-2,3-DIONES AND THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1994-08-10 | — | — | EP | disclosed |
| US-5284847-A | Neurological and psychological disorders; antagonist at the glycine binding site on the N-methyl-D-aspartate receptor complex | NOVO NORDISK A/S (DK) | 1994-02-08 | — | — | US | disclosed |
| WO-1993008197-A1 | THIENOPYRAZINE-2,3-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-04-29 | — | — | WO | disclosed |
| EP-0315899-B1 | THIEN-3-YL AZO DYES | BASF Aktiengesellschaft (DE) | 1993-04-07 | — | — | EP | disclosed |
| EP-0483683-A2 | Thienoimidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-05-06 | — | — | EP | disclosed |
| US-4994564-A | Dyeing synthetic fibers in shades of red, yellow | BASF AKTIENGESELLSCHAFT (DE) | 1991-02-19 | — | — | US | disclosed |
| EP-0315899-A2 | Thien-3-yl azo dyes | BASF Aktiengesellschaft (DE) | 1989-05-17 | — | — | EP | disclosed |