Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28645315 | 0.86 | PLA2G1B (0.37) | ALDH1A1HPGDGAAADORA2AKDM4E | |
| SCHEMBL7978240 | 0.84 | ALDH1A1 (0.45) | ALDH1A1HPGDGAAADORA2AKDM4E | |
| SCHEMBL7979698 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HPGDGAAADORA2AKDM4E | |
| SCHEMBL18430437 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HPGDGAAADORA2AKDM4E | |
| SCHEMBL27469752 | 0.74 | KMT2A (0.40) | ALDH1A1HPGDGAAADORA2AKDM4E | |
| SCHEMBL7965913 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HPGDGAAKDM4EKMT2A | |
| SCHEMBL8582491 | 0.71 | ALDH1A1 (0.45) | ALDH1A1HPGDGAAKDM4EPLA2G1B | |
| SCHEMBL13861203 | 0.70 | ALDH1A1 (0.47) | ALDH1A1HPGDGAAADORA2AKDM4E | |
| SCHEMBL13984089 | 0.70 | L3MBTL1 (0.41) | ALDH1A1HPGDGAAADORA2AKDM4E | |
| SCHEMBL3050182 | 0.68 | ADORA2A (0.55) | ALDH1A1HPGDGAAADORA2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225310-B1 | Fused 1,2,4-thiadiazine derivatives, their preparation and use | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1000066-A1 | FUSED 1,2,4-THIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999003861-A1 | FUSED 1,2,4-THIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-01-28 | — | — | WO | disclosed |