SCHEMBL27469752

SCHEMBL27469752

COC(=O)c1sc(C)c(C#N)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.40
TSHR P16473 2/20 0.40
HSD17B10 Q99714 2/20 0.40
MAPT P10636 1/20 0.40
PLA2G1B P04054 1/20 0.40
ATG4B Q9Y4P1 1/20 0.40
ALDH1A1 P00352 6/20 0.39
RXFP1 Q9HBX9 2/20 0.39
MEN1 O00255 1/20 0.39
HPGD P15428 4/20 0.39
GAA P10253 1/20 0.39
MAPK1 P28482 2/20 0.39
ADORA2A P29274 1/20 0.38
KDM4E B2RXH2 2/20 0.38
APOBEC3G Q9HC16 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
COMT P21964 1/20 0.35
BRAF P15056 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18430437 0.82 ALDH1A1 (0.50) KMT2ATSHRHSD17B10MAPTPLA2G1B
SCHEMBL7979698 0.79 ALDH1A1 (0.46) KMT2ATSHRHSD17B10MAPTALDH1A1
SCHEMBL23531547 0.77 MAPT (0.41) KMT2ATSHRHSD17B10MAPTPLA2G1B
SCHEMBL23531571 0.76 ALDH1A1 (0.48) KMT2ATSHRHSD17B10MAPTPLA2G1B
SCHEMBL28645315 0.76 PLA2G1B (0.37) KMT2ATSHRHSD17B10MAPTPLA2G1B
SCHEMBL13861203 0.75 ALDH1A1 (0.47) KMT2ATSHRHSD17B10MAPTPLA2G1B
SCHEMBL13984089 0.74 L3MBTL1 (0.41) KMT2ATSHRHSD17B10MAPTPLA2G1B
SCHEMBL7982273 0.74 ALDH1A1 (0.38) KMT2ATSHRHSD17B10MAPTPLA2G1B
SCHEMBL9827011 0.73 KMT2A (0.44) KMT2ATSHRHSD17B10MAPTALDH1A1
SCHEMBL6207819 0.71 ALDH1A1 (0.46) KMT2AHSD17B10MAPTPLA2G1BATG4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1143855-C I (ortho)-anthranilamide derivatives as anti-coagulants ���ֹɷݹ�˾ 2004-03-31 CN disclosed
CN-1282329-A I (ortho)-anthranilamide derivatives as anti-coagulants SCHERING AG (DE) 2001-01-31 CN disclosed