Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8014754 | 0.90 | ALDH1A1 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL8014750 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL21306553 | 0.82 | CES2 (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL16689961 | 0.77 | KMT2A (0.67) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL13366184 | 0.76 | MAPT (0.55) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL15536378 | 0.75 | ALDH1A1 (0.51) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL674080 | 0.75 | ALDH1A1 (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL8420960 | 0.74 | HDAC4 (0.44) | SMN1; SMN2RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL15128314 | 0.74 | PTPN1 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL678301 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297267-B1 | PROSTAGLANDIN I2 AGONIST. | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-02 | — | — | US | disclosed |
| EP-1027340-A1 | 4, 5-DIARYLOXAZOLE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999021843-A1 | 4, 5-DIARYLOXAZOLE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-05-06 | — | — | WO | disclosed |