Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 11/20 | 0.42 |
| ▸ | FNTB | P49356 | 11/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 11/20 | 0.42 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984249 | 0.81 | S1PR3 (0.38) | RORCCYP19A1 | |
| SCHEMBL7981909 | 0.78 | ACSS2 (0.38) | RORCCYP19A1 | |
| SCHEMBL3498531 | 0.73 | CYP19A1 (0.54) | FNTAFNTBPGGT1BRORCAR | |
| SCHEMBL2915674 | 0.72 | CYP3A4 (0.41) | FNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL7984344 | 0.70 | CYP19A1 (0.37) | RORCCYP19A1CNR1CNR2 | |
| SCHEMBL3500514 | 0.70 | FNTA (0.57) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7981694 | 0.69 | FNTA (0.56) | FNTAFNTBPGGT1B | |
| SCHEMBL5750972 | 0.67 | ACSS2 (0.45) | CYP19A1CNR1 | |
| SCHEMBL7710617 | 0.66 | CYP11B1 (0.34) | ARSLC22A12 | |
| SCHEMBL1481864 | 0.65 | KIF11 (0.39) | RORCCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1021188-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017777-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |