Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 5/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915674 | 0.94 | CYP3A4 (0.41) | ACSS2CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL7984249 | 0.84 | S1PR3 (0.38) | CYP19A1CYP3A4CYP3A5RORC | |
| SCHEMBL2918068 | 0.83 | CYP19A1 (0.39) | ACSS2CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL7980280 | 0.78 | FNTA (0.42) | CYP19A1RORC | |
| SCHEMBL7984344 | 0.77 | CYP19A1 (0.37) | CYP19A1CYP3A4CYP3A5RORC | |
| SCHEMBL5688661 | 0.73 | CYP17A1 (0.44) | CYP19A1CYP3A4RORC | |
| SCHEMBL4032019 | 0.73 | ACSS2 (0.38) | ACSS2CYP3A4RORC | |
| SCHEMBL5689382 | 0.72 | CYP17A1 (0.43) | ACSS2CYP3A4RORC | |
| SCHEMBL914557 | 0.71 | CYP3A4 (0.57) | ACSS2CYP19A1CYP3A4CYP3A5MAOA | |
| SCHEMBL2787655 | 0.71 | CYP19A1 (0.36) | ACSS2CYP19A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |