Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.58 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.58 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 5/20 | 0.57 |
| ▸ | BRD4 | O60885 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GPR3 | P46089 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983954 | 0.85 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL7983972 | 0.80 | KDM4E (0.77) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL31195781 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL7983948 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL2895978 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL1292034 | 0.75 | GRIN2D (1.00) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL20597299 | 0.75 | ABCG2 (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL14280975 | 0.74 | CA1 (0.55) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL2553439 | 0.74 | GRIN2D (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL7985105 | 0.74 | GRIN2D (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |