Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | ATM | Q13315 | 1/20 | 0.77 |
| ▸ | AHR | P35869 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | CTSV | O60911 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | GABRP | O00591 | 1/20 | 0.56 |
| ▸ | GABRD | O14764 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15926660 | 0.89 | KDM4E (0.73) | KDM4EMAPTATMAHRALDH1A1 | |
| SCHEMBL4143973 | 0.87 | MAPT (1.00) | KDM4EMAPTATMAHRALDH1A1 | |
| Terephthalic Acid SCHEMBL29145293 | 0.86 | KDM4E (0.60) | KDM4EMAPTATMAHRALDH1A1 | |
| SCHEMBL4259365 | 0.86 | KDM4E (0.69) | KDM4EMAPTATMAHRALDH1A1 | |
| SCHEMBL7983948 | 0.85 | KDM4E (0.61) | KDM4EMAPTATMALDH1A1HSD17B10 | |
| SCHEMBL31195781 | 0.85 | KDM4E (0.61) | KDM4EMAPTATMALDH1A1HSD17B10 | |
| Glycosinine SCHEMBL30839690 | 0.82 | KDM4E (0.63) | KDM4EMAPTATMAHRALDH1A1 | |
| Bromide SCHEMBL9017450 | 0.81 | KDM4E (0.61) | KDM4EMAPTATMAHRALDH1A1 | |
| SCHEMBL7980984 | 0.80 | KDM4E (0.62) | KDM4EMAPTATMALDH1A1HSD17B10 | |
| SCHEMBL12219478 | 0.79 | AHR (1.00) | KDM4EMAPTATMAHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |