Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27496885 | 0.89 | LMNA (0.51) | LMNAMAPK1L3MBTL1TDP1ATM | |
| SCHEMBL87423 | 0.85 | PRNP (0.48) | LMNAMAPK1TDP1MEN1KMT2A | |
| SCHEMBL9811801 | 0.75 | MAOB (0.50) | LMNAMAPK1L3MBTL1TDP1MEN1 | |
| SCHEMBL7985137 | 0.75 | WDR5 (0.51) | LMNAMAPK1TDP1MEN1KMT2A | |
| SCHEMBL25904738 | 0.75 | LMNA (0.82) | LMNAMAPK1L3MBTL1TDP1ATM | |
| SCHEMBL19758774 | 0.75 | IKBKB (0.46) | LMNAMAPK1TDP1ATMMEN1 | |
| SCHEMBL29450544 | 0.74 | PRNP (0.51) | MAPK1TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL4587587 | 0.74 | PRNP (0.51) | MAPK1TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL30536707 | 0.74 | MEN1 (0.42) | TDP1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1667159 | 0.73 | NCEH1 (0.56) | LMNAMAPK1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300340-B1 | USEFUL FOR THERAPY OF CANCER AND SOLID TUMORS | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |
| US-6162822-A | Bisimide compounds | ADIR ET COMPAGNIE (FR) | 2000-12-19 | — | — | US | disclosed |
| US-5854273-A | Bisimide compounds | ADIR ET COMPAGNIE (FR) | 1998-12-29 | — | — | US | disclosed |
| CN-1182086-A | New bisimide compounds, process for preparing them and pharmaceutical compositions containing them | ADIR (FR) | 1998-05-20 | — | — | CN | disclosed |