Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981572 | 0.86 | NOX4 (0.68) | SRCNOX4PRKACAPRKACGPRKACB | |
| SCHEMBL7980591 | 0.85 | TSHR (0.52) | SRCTP53KMT2AMEN1HTT | |
| SCHEMBL7980495 | 0.83 | SRC (0.49) | SRCPRKACAPRKACGPRKACBKMT2A | |
| SCHEMBL7987028 | 0.82 | SRC (0.57) | SRCPRKACAPRKACGPRKACBTP53 | |
| SCHEMBL7981431 | 0.78 | SRC (0.48) | SRCTP53KMT2AMEN1HTT | |
| SCHEMBL6679443 | 0.77 | TP53 (0.51) | SRCNOX4PRKACAPRKACGPRKACB | |
| SCHEMBL6679445 | 0.73 | KMT2A (0.40) | SRCNOX4PRKACAPRKACGPRKACB | |
| SCHEMBL7987368 | 0.72 | SRC (1.00) | SRCNOX4PRKACAPRKACGPRKACB | |
| SCHEMBL7987031 | 0.70 | NOX4 (0.54) | SRCNOX4PRKACAPRKACGPRKACB | |
| SCHEMBL11445232 | 0.69 | KMT2A (0.53) | SRCNOX4PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |