Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 6/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980591 | 0.86 | TSHR (0.52) | SRCKDM4ETHRBALDH1A1TSHR | |
| SCHEMBL7983884 | 0.85 | SRC (0.67) | SRCPRKACAPRKACGPRKACBCCR2 | |
| SCHEMBL7981786 | 0.83 | SRC (0.56) | SRCPRKACAPRKACGPRKACBKDM4E | |
| SCHEMBL7987028 | 0.81 | SRC (0.57) | SRCPRKACAPRKACGPRKACBKDM4E | |
| SCHEMBL7981431 | 0.80 | SRC (0.48) | SRCKDM4EALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7987031 | 0.72 | NOX4 (0.54) | SRCPRKACAPRKACGPRKACBTSHR | |
| SCHEMBL7987637 | 0.70 | SRC (0.74) | SRCPRKACAPRKACGPRKACBCCR2 | |
| SCHEMBL7980285 | 0.70 | SRC (0.49) | SRCKDM4ETHRBALDH1A1BLM | |
| SCHEMBL7970086 | 0.70 | SRC (0.63) | SRCPRKACAPRKACGPRKACBKDM4E | |
| SCHEMBL7970968 | 0.69 | TSHR (0.47) | SRCKDM4EALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |