Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | PRKACG | P22612 | 1/20 | 0.53 |
| ▸ | PRKACB | P22694 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980591 | 0.90 | TSHR (0.52) | SRCTSHRALDH1A1HSD17B10HTT | |
| SCHEMBL7983968 | 0.87 | SRC (0.56) | SRCPRKACAPRKACGPRKACBTSHR | |
| SCHEMBL7987031 | 0.86 | NOX4 (0.54) | SRCPRKACAPRKACGPRKACBTSHR | |
| SCHEMBL7970466 | 0.86 | SRC (0.69) | SRCPRKACAPRKACGPRKACBTSHR | |
| SCHEMBL7981786 | 0.82 | SRC (0.56) | SRCPRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL7980495 | 0.81 | SRC (0.49) | SRCPRKACAPRKACGPRKACBTSHR | |
| SCHEMBL7981431 | 0.79 | SRC (0.48) | SRCTSHRALDH1A1HSD17B10HTT | |
| SCHEMBL7970086 | 0.74 | SRC (0.63) | SRCPRKACAPRKACGPRKACBTSHR | |
| SCHEMBL7970968 | 0.73 | TSHR (0.47) | SRCTSHRALDH1A1HSD17B10HTT | |
| SCHEMBL7981604 | 0.73 | SRC (1.00) | SRCPRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |