Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17669678 | 0.80 | NR4A1 (0.50) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3304455 | 0.77 | ALDH1A1 (0.54) | GAAMGLLHCAR1MEN1KMT2A | |
| SCHEMBL31361518 | 0.76 | HCAR1 (0.49) | GAAMGLLHCAR1MEN1KMT2A | |
| SCHEMBL17669676 | 0.76 | HTT (0.50) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3433008 | 0.76 | GAA (0.60) | GAAMGLLHCAR1MEN1KMT2A | |
| SCHEMBL9529067 | 0.75 | CYP1A2 (0.60) | GAAMAPT | |
| SCHEMBL10059782 | 0.75 | ALDH1A1 (0.49) | GAAMGLLHCAR1MEN1KMT2A | |
| SCHEMBL10059776 | 0.75 | GAA (0.45) | GAAMGLLHCAR1MEN1KMT2A | |
| SCHEMBL16104143 | 0.75 | MGLL (0.48) | MGLLHCAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL2098026 | 0.74 | CA12 (0.52) | GAAMGLLMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1021188-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017777-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |