Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14817119 | 0.88 | RAB9A (0.45) | HTTGAAHPGDTSHRKMT2A | |
| SCHEMBL23865283 | 0.87 | PTGIR (0.49) | PTGIRGAAHPGDTSHRKMT2A | |
| SCHEMBL6341084 | 0.87 | GAA (0.41) | HTTKCNA5PTGIRGAAHPGD | |
| SCHEMBL7982157 | 0.84 | NPSR1 (0.47) | HTTKCNA5NPSR1TSHRALDH1A1 | |
| SCHEMBL741752 | 0.82 | NPSR1 (0.64) | HTTNPSR1GAAHPGDTSHR | |
| SCHEMBL7112425 | 0.82 | KCNA5 (0.47) | HTTKCNA5PTGIRNPSR1GAA | |
| SCHEMBL1648430 | 0.82 | KCNA5 (0.47) | HTTKCNA5PTGIRNPSR1GAA | |
| SCHEMBL12782094 | 0.82 | ALDH1A1 (0.51) | NPSR1GAAHPGDALDH1A1MEN1 | |
| SCHEMBL3929961 | 0.81 | GRM5 (0.49) | KCNA5GAAHPGDTSHRALDH1A1 | |
| SCHEMBL16398787 | 0.81 | GAA (0.50) | HTTKCNA5PTGIRNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101203495-B | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK SHARP & DOHME | 2013-07-17 | — | — | CN | claimed |
| CN-102731499-B | Lactam compound and the application as medicine thereof | Because of C1-esteraseremmer-N parent corporation (US) | 2016-01-13 | — | — | CN | disclosed |
| CN-101203495-B | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK SHARP & DOHME | 2013-07-17 | — | — | CN | disclosed |
| CN-103087078-A | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LAB | 2013-05-08 | — | — | CN | disclosed |
| CN-102007127-A | Furo- and thieno [3,2-c] pyridines | OSI PHARM INC | 2011-04-06 | — | — | CN | disclosed |
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| CN-1252068-A | 3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions containing the same | JAPAN TOBACCO INC (JP) | 2000-05-03 | — | — | CN | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |