Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9852608 | 0.89 | HRH3 (0.54) | SIGMAR1HRH3OPRM1GRIN2BDRD2 | |
| SCHEMBL8120677 | 0.82 | SIGMAR1 (0.52) | SIGMAR1POLBOPRM1HTR2CDRD3 | |
| SCHEMBL7982882 | 0.77 | SIGMAR1 (0.53) | SIGMAR1LTA4HHRH3POLBGRIN2B | |
| SCHEMBL7984485 | 0.77 | NAMPT (0.60) | SIGMAR1LTA4HHRH3POLBGRIN2B | |
| SCHEMBL10382817 | 0.76 | SIGMAR1 (0.58) | SIGMAR1LTA4HPOLBOPRM1GRIN2B | |
| SCHEMBL10383389 | 0.75 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL21120585 | 0.75 | TMEM97 (0.56) | SIGMAR1HTR2CDRD3 | |
| Hydrochloric Acid SCHEMBL10398018 | 0.74 | OPRM1 (0.56) | HRH3OPRM1GRIN2BDRD2HTR2A | |
| SCHEMBL15787911 | 0.74 | L3MBTL3 (0.51) | HRH3GRIN2BNAMPTDRD2HTR2A | |
| SCHEMBL7985762 | 0.72 | OPRM1 (0.43) | SIGMAR1LTA4HHRH3OPRM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| CN-1223659-A | Fused imidazopyridine derivatives as antihyperlipidemic agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |