Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 7/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979828 | 0.84 | LCK (0.48) | PDE2ALCKPDE10A | |
| SCHEMBL7987029 | 0.83 | LCK (0.45) | CDK9PDE2ALCKPDE10A | |
| SCHEMBL7969613 | 0.82 | PDE2A (0.38) | CDK9PDE2ALCKPDE10A | |
| SCHEMBL7982991 | 0.82 | LCK (0.43) | CDK9PDE2ACCNT1LCKPDE10A | |
| SCHEMBL7987537 | 0.81 | LCK (0.42) | CDK9PDE2ACCNT1LCKPDE10A | |
| SCHEMBL7983613 | 0.81 | LCK (0.51) | PDE2AADORA2AADORA1CCNT1LCK | |
| SCHEMBL7983672 | 0.80 | FGFR1 (0.53) | LCK | |
| SCHEMBL7980015 | 0.79 | LCK (0.52) | PDE2ALCK | |
| SCHEMBL7969597 | 0.79 | PDE2A (0.46) | NPC1CDK9PDE2AADORA2AADORA1 | |
| SCHEMBL7970503 | 0.79 | CAMK2D (0.43) | NPC1PDE2ALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |