Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983154 | 1.00 | KDM4E (0.35) | KDM4EKMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL8350478 | 0.85 | DHODH (0.37) | KMT2ADHODHLMNAALDH1A1SCN3A | |
| SCHEMBL7976972 | 0.85 | DHODH (0.37) | KMT2ADHODHLMNAALDH1A1SCN3A | |
| SCHEMBL7976973 | 0.85 | DHODH (0.37) | KMT2ADHODHLMNAALDH1A1SCN3A | |
| SCHEMBL8351808 | 0.83 | L3MBTL1 (0.37) | KMT2AL3MBTL1DHODHLMNASMN1; SMN2 | |
| SCHEMBL8351806 | 0.83 | L3MBTL1 (0.37) | KMT2AL3MBTL1DHODHLMNASMN1; SMN2 | |
| SCHEMBL5725518 | 0.79 | ENO1 (0.31) | LMNASMN1; SMN2 | |
| SCHEMBL5725539 | 0.73 | HTR2C (0.47) | KMT2AL3MBTL1LMNA | |
| SCHEMBL5725534 | 0.73 | HTR2C (0.47) | KMT2AL3MBTL1LMNA | |
| SCHEMBL5724839 | 0.73 | CHRM3 (0.45) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174909-B1 | FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE | H. LUNDBECK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| US-5998613-A | PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 1999-12-07 | — | — | US | disclosed |