Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.43 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478543 | 0.91 | HRH3 (0.49) | CA12CA1CA2CA9MAPT | |
| SCHEMBL9478237 | 0.87 | TP53 (0.56) | CA12CA1CA2CA9KCNA1 | |
| SCHEMBL9478847 | 0.86 | MEN1 (0.47) | CA1CA2CA9EPHX2KCNA1 | |
| SCHEMBL9478381 | 0.85 | CA1 (0.46) | CA12CA1CA2CA9KCNA1 | |
| SCHEMBL7983217 | 0.85 | KCNA1 (0.53) | CA12CA1CA2CA9MAPT | |
| SCHEMBL9479492 | 0.84 | CA1 (0.40) | CA12CA1CA2CA9MAPT | |
| SCHEMBL9478768 | 0.84 | CA2 (0.44) | CA1CA2CA9MAPTKCNA1 | |
| SCHEMBL9477487 | 0.83 | MEN1 (0.60) | CA12CA2CA9MAPTKCNA1 | |
| SCHEMBL9477595 | 0.81 | EPHX1 (0.47) | CA12CA1CA2CA9MAPT | |
| SCHEMBL9478165 | 0.81 | MEN1 (0.48) | CA12CA1CA2CA9KCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |