Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987343 | 0.88 | HTR2A (0.38) | HTR2AKDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8111113 | 0.80 | CYP19A1 (0.47) | CYP19A1HTR2ACYP3A4MAPTALOX15 | |
| SCHEMBL9816167 | 0.79 | HTR2A (0.40) | HTR2AKDM4EMEN1ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL9719344 | 0.78 | CYP19A1 (0.46) | CYP19A1HTR2ACYP3A4MAPTALOX15 | |
| SCHEMBL7983255 | 0.76 | LOXL2 (0.39) | HTR2AKDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL7987634 | 0.74 | ADRB2 (0.39) | BCL2ALOX15 | |
| SCHEMBL9269160 | 0.73 | CYP19A1 (0.41) | CYP19A1HTR2ACYP3A4ALOX15MAOA | |
| SCHEMBL9266327 | 0.73 | CYP19A1 (0.41) | CYP19A1HTR2ACYP3A4ALOX15MAOA | |
| SCHEMBL30779227 | 0.73 | HTR2A (0.40) | HTR2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8840931 | 0.71 | CES2 (0.41) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |