Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983280 | 0.76 | CYP19A1 (0.39) | MAPTSMN1; SMN2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL7987343 | 0.74 | HTR2A (0.38) | MAPTSMN1; SMN2CYP3A4KDM4ELMNA | |
| SCHEMBL7980300 | 0.74 | LOXL2 (0.45) | LOXL2MAPTSMN1; SMN2TP53NPC1 | |
| SCHEMBL9816167 | 0.71 | HTR2A (0.40) | MAPTSMN1; SMN2ESR1CYP3A4KDM4E | |
| SCHEMBL8840931 | 0.67 | CES2 (0.41) | HTR2A | |
| SCHEMBL7983609 | 0.63 | PDE10A (0.47) | LOXL2MAPTSMN1; SMN2TP53NPC1 | |
| SCHEMBL7988320 | 0.63 | MAPT (0.44) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL7988321 | 0.63 | MAPT (0.44) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL31599195 | 0.63 | LOXL2 (0.67) | LOXL2MAPTSMN1; SMN2TP53NPC1 | |
| SCHEMBL334360 | 0.63 | LOXL2 (0.67) | LOXL2MAPTSMN1; SMN2TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |