Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31222334 | 0.85 | RIPK1 (0.46) | RIPK1MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL28228308 | 0.81 | ALDH1A1 (0.53) | GRM5ALDH1A1LMNAHSD17B1HSD17B2 | |
| SCHEMBL14267705 | 0.80 | SIGMAR1 (0.43) | GRM5ALDH1A1LMNAMEN1POLB | |
| SCHEMBL7221157 | 0.80 | GRM5 (0.45) | RIPK1GRM5KMT2AL3MBTL1SIGMAR1 | |
| SCHEMBL1400933 | 0.79 | MTNR1A (0.48) | RIPK1MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL2378380 | 0.79 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1LMNAMEN1 | |
| SCHEMBL6555780 | 0.79 | MAPT (0.44) | ALDH1A1LMNAMAPTNPSR1L3MBTL1 | |
| SCHEMBL4746141 | 0.78 | KMT2A (0.51) | ALDH1A1MEN1POLBKMT2ANPSR1 | |
| SCHEMBL11541741 | 0.77 | MTNR1A (0.43) | RIPK1MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL10947337 | 0.77 | MTNR1A (0.43) | RIPK1MTNR1AMTNR1BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | disclosed |