Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6906579 | 0.83 | LMNA (0.50) | MAPTKMT2AALDH1A1MEN1ACHE | |
| SCHEMBL7983422 | 0.81 | MAPT (0.44) | MAPTKMT2AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL7980653 | 0.80 | MAPT (0.40) | MAPTKMT2AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL7977148 | 0.80 | MAPT (0.40) | MAPTKMT2AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL7980852 | 0.80 | MAPT (0.40) | MAPTKMT2AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL7983419 | 0.77 | ALOX15 (0.52) | MAPTKMT2AHSD17B10KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7165428 | 0.76 | LMNA (0.57) | MAPTKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL6912324 | 0.73 | KIF11 (0.42) | MAPTKMT2AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL6905934 | 0.73 | KIF11 (0.42) | MAPTKMT2AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL6912027 | 0.73 | KIF11 (0.42) | MAPTKMT2AHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |