Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984054 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9372932 | 0.82 | TUBB4A (0.47) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL7970224 | 0.75 | CYP19A1 (0.41) | CYP19A1 | |
| SCHEMBL7983609 | 0.70 | PDE10A (0.47) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL1114939 | 0.70 | PDE4D (0.81) | PDE4DCYP19A1 | |
| SCHEMBL7980288 | 0.70 | KCNH2 (0.47) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8111113 | 0.68 | CYP19A1 (0.47) | CYP19A1SMN1; SMN2 | |
| SCHEMBL4087810 | 0.68 | TSHR (0.42) | PDE4DKDM4EALDH1A1GAAPDE4A | |
| Hydrochloric Acid SCHEMBL9719344 | 0.67 | CYP19A1 (0.46) | CYP19A1SMN1; SMN2 | |
| SCHEMBL7604783 | 0.67 | KDM4E (0.66) | KDM4EALDH1A1GLACYP19A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |