Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.42 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980300 | 0.80 | LOXL2 (0.45) | RIPK2LOXL2MAPTKDM4EMEN1 | |
| SCHEMBL7983806 | 0.75 | PDE10A (0.40) | PDE10AGAKRIPK2COQ8ANLK | |
| SCHEMBL11819246 | 0.74 | PDE10A (0.56) | PDE10AAPPMAPTKDM4EALDH1A1 | |
| SCHEMBL7984054 | 0.72 | KDM4E (0.45) | MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL828159 | 0.71 | GAK (0.55) | PDE10AGAKRIPK2COQ8ANLK | |
| Iodide SCHEMBL14236729 | 0.69 | GAK (0.54) | PDE10AGAKRIPK2COQ8ANLK | |
| Iodide SCHEMBL14236731 | 0.69 | GAK (0.54) | PDE10AGAKRIPK2COQ8ANLK | |
| SCHEMBL7669074 | 0.68 | ACACA (0.59) | GAKRIPK2COQ8ANLKKDM4E | |
| SCHEMBL7983642 | 0.68 | CYP11B2 (0.44) | PDE10AGAKRIPK2COQ8ANLK | |
| SCHEMBL27931314 | 0.68 | PDE10A (0.63) | PDE10APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |