Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.44 |
| ▸ | DRD1 | P21728 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979301 | 0.89 | ALOX15 (0.41) | ADRB2ADRB1DRD2DRD3DRD1 | |
| SCHEMBL7979336 | 0.85 | ADRB1 (0.42) | ADRB2ADRB1DRD2DRD3DRD1 | |
| SCHEMBL7967383 | 0.84 | ALOX15 (0.51) | ADRB2ADRB1ALOX15ADRB3ALDH1A1 | |
| SCHEMBL7977145 | 0.84 | ALOX15 (0.51) | ADRB2ADRB1ALOX15ADRB3ALDH1A1 | |
| SCHEMBL7980850 | 0.84 | ALOX15 (0.51) | ADRB2ADRB1ALOX15ADRB3ALDH1A1 | |
| SCHEMBL7068691 | 0.83 | ADRB2 (0.50) | ADRB2ADRB1DRD2DRD3DRD1 | |
| SCHEMBL7980797 | 0.82 | ADRB3 (0.51) | ADRB2ADRB1ADRB3 | |
| SCHEMBL7979295 | 0.77 | ALOX15 (0.41) | ADRB2ADRB1ALOX15ADRB3ALDH1A1 | |
| SCHEMBL7983735 | 0.77 | MAPT (0.42) | ALDH1A1MEN1LMNAMAPTKMT2A | |
| SCHEMBL7980718 | 0.76 | ADRB2 (0.46) | ADRB2ADRB1DRD2DRD3ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |